Advancing
first-in-class
therapies to
restore energy
homeostasis

OrsoBio is developing novel approaches to treat patients with severe metabolic disorders, including obesity, diabetes, severe dyslipidemias, MASH, and more.

OrsoBio’s therapies target fundamental pathways of energy metabolism, and our team of physicians and scientists draw on decades of drug development experience.

Our Team

The OrsoBio team is a group of forward-thinking scientists and proven biotech leaders who are deeply committed to advancing new therapies to help patients with severe metabolic disorders. Our mission is to redefine the treatment of these disorders by addressing their root cause.

The OrsoBio Approach

Addressing High
Unmet Medical Needs

Focusing on severe metabolic disorders with major morbidity and mortality

Restoring Energy Homeostasis

Targeting fundamental aspects of metabolism with first-in-class therapies to restore energy homeostasis and improve clinical outcomes

Exceptional Team of Experts

Dedicated MDs and PhDs with decades of clinical and drug development experience

Latest from OrsoBio

TLC-1180, a Protonophore, with Semaglutide Enhances Weight Loss and Preserves Lean Mass in DIO Mic (ObesityWeek 2025, Oral #013)

Exclusive: Lilly-backed OrsoBio raises $67M for slate of obesity drugs as combinations take root

Biopharmaceutical company OrsoBio Logo - silhouette of a purple bear with an orange flame

Recent News

OrsoBio team members collaborated with Professor Takebe in his pioneering study in Cell on the first use of en masse human liver organoids to define the genetic basis of metabolic liver disease and potential for tailored therapeutic development.